The Best Retinol Formulas to Buy at the Drugstore, According to Dermatologists

You’ll find retinol in many prestige skincare formulas but, for quite some time, it was harder to track down more affordable options. Thankfully, more and more drugstore brands are making the miracle ingredient accessible to the masses. A host of products — even entire lines — boast retinol as part of their DNA.

Read on as dermatologists share some of their favorite retinol-spiked serums, gels, and lotions to help you start reaping the benefits as soon as possible. (Be sure to consult your own derm should you have questions about which retinol solution is right for your individual needs.)

Best Retinol Face Cream According To Dermatologists 

Tree of Life Vitamin C, Retinol and Hyaluronic Acid Serum

Tree of Life Beauty Facial Skin Care Set, Brightening, Firming, Hydrating, Dry Face, Dermatologist Tested - Trio Power Kit, Vitamin C, Retinol and Hyaluronic Acid, 3 count of 1 Fl Oz
  • POWERFUL ANTI-AGING TRIO: This set includes our beloved Vitamin C Serum to brighten and even skin tone, Retinol Serum to reduce fine lines and wrinkles, and Hyaluronic Acid Serum for deep hydration. Used together, these potent serums visibly improve skin texture, tone, and firmness for a more youthful complexion. Suitable for all skin types including sensitive skin. See noticeable results in as little as 2-4 weeks with consistent use.
  • ADVANCED FORMULA: Our serums are packed with nourishing botanical ingredients like aloe vera, jojoba oil, and witch hazel. We use high-quality, active ingredients in effective concentrations. Vegan and cruelty-free.

Tree of Life Vitamin C, Retinol and Hyaluronic Acid Serum says it’s important to remember that consistency is key when it comes to retinol. Unfortunately, consistency can be difficult when retinol increases flakiness, redness, and peeling as your skin gets used to it — an ordinary side effect of retinol.

RoC® Retinol Correxion® Deep Wrinkle Night Face Cream

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RoC Retinol Correxion Deep Wrinkle Anti-Aging Night Cream, Daily Face Moisturizer with Shea Butter, Glycolic Acid and Squalane, Stocking Stuffers for Men & Women, 1 Ounces (Packaging May Vary)
  • DEEP WRINKLE NIGHT CREAM: This anti-aging hydrating cream with glycerin works through the night when skin is believed to be most receptive. Wake up to revitalized skin for a smoother, more radiant appearance.
  • FOR DAILY USE: Powered by Retinol & our exclusive mineral complex, this non-greasy, non-comedogenic formula helps reduce the appearance of deep wrinkles by up to 50% while lifting & firming skin*. Made for dramatic results but gentle enough for daily use by men and women.

“Ideally, retinol should be moisturizing enough to be used seven days a week, 365 days a year,” she says, citing RoC® Retinol Correxion® Deep Wrinkle Night Face Cream ($15) as an option. “The more hydrating the formula, the more likely patients are to be compliant with its use.”

Differin® Gel

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Differin Acne Treatment Gel, 30 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 15g Tube (Packaging May Vary)
  • TARGETS ACNE: Clears breakouts where they start (Deep in pores) and prevents new acne from forming, which ultimately restores skin's texture and tone
  • CLEARS, TREATS & PREVENTS: Differin works differently than other Acne treatments by normalizing skin cell turnover and effectively targets two primary causes of Acne, clogged pores and inflammation

Previously only available with a prescription, Differin® Gel ($13) is one of the most lauded formulas for acne treatment. Dr. Jenny Sobera, FAAD, Co-Founder and Chief Medical Officer of FaceMD+TM, has been recommending the product to patients for years. “With regular use, you can typically expect to see improvement when it comes to clearing acne, as well as improved texture.”

Neutrogena® Rapid Wrinkle Repair® Face and Neck Moisturizer with SPF 30 

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Neutrogena Retinol Face Moisturizer, Rapid Wrinkle Repair with SPF 30 Sunscreen, Daily Anti-Aging Face Cream with Retinol & Hyaluronic Acid to Fight Fine Lines, Wrinkles, & Dark Spots, 1 fl. oz
  • 1-fluid ounce pump bottle of Neutrogena Visible Repair Retinol Face & Neck Cream Moisturizer with Broad Spectrum SPF 30, retinol & hyaluronic acid. Your Rapid Wrinkle Repair anti-aging moisturizer got a makeover, a new look with the same efficacy
  • Anti-wrinkle face & neck moisturizer with retinol intended for beginners has been dermatologist-tested & has proven to smooth skin & improve skin clarity in one week & in just four weeks, reduce the look of fine lines & dark spots

For a less intense retinol formula, Dr. Sobera recommends the Neutrogena® Rapid Wrinkle Repair® Face and Neck Moisturizer with SPF 30 ($18). “Not only does it offer a low dose of retinol, but it also contains hydrating and calming hyaluronic acid and protective SPF 30,” she says. For these reasons, the product is worth a shot if you have sensitive skin. According to the brand, you can expect to see results — including a reduction in the appearance of fine crow’s feet and cheek wrinkles — in as little as one week. That said, retinoids can take months of consistent use before showing any visible improvement.

MD CompleteTM Retinol Vitamin C Concentrate

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Dr. Hal Weitzbuch, MS, FAAD, Director at the Calabasas Dermatology CenterTM, loves the MD CompleteTM Retinol Vitamin C Concentrate ($29) for its antioxidant benefits. “In addition to containing retinol, the formula is packed with vitamins C and E, pomegranate, cumin, and coconut oil,” he says. Unlike many products containing vitamin C, this one should be applied at night before moisturizer, he notes, as retinol can degrade when exposed to sunlight.

The Ordinary Retinol Serum 1% in Squalane

Eva Naturals Anti-Aging 1% Retinol Serum For Face - Granactive Retinoid with Squalane Dark Spots, Fine Lines & Wrinkles - Collagen Boosting Moisturizer - Pure Retinol Night Serum for Face (2 Oz)
  • Smooth Blemishes, Brighten Skin: Our Retinol + Squalane Serum works to provide powerful exfoliation, fading dark spots and reducing blemishes, while remaining gentle enough for even sensitive skin types.
  • Powerful Anti-Aging Serum: Enjoy the rejuvenating effects of squalane and aloe as they provide your skin with refreshing moisturization, making your skin appear younger and smoother, and silky smooth!

The Ordinary® has set skincare lovers abuzz, and it turns out that derms are also loving the brand. “[The brand has] great products that are sold at unbeatable prices,” Dr. Weitzbuch says. He particularly loves The Ordinary Retinol Serum 1% in Squalane ($7)“Vegan and cruelty free, this retinol serum is a great complement to any skincare regimen,” he says. “Like most serums, it should be applied after cleansing before moisturizing.” In addition to retinol, the product is also laced with squalane, a skin-softening superhero. (Read more about squalane here.)

Olay® Regenerist® Intensive Repair Treatment

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Olay Smooth & Renew Retinol Face Moisturizer, 2 oz Fragrance Free Night Cream for Fine Lines and Wrinkles with Retinoid Complex, Recyclable Eco Jar Packaging, Value Size
  • NIGHTTIME SKIN CARE: Apply before bedtime to wake up to smooth, younger-looking and brighter skin
  • POWERFUL INGREDIENTS: Features Olay's Niacinamide + Retinoid Complex, plus Amino Peptides

Dr. Howard Sobel, a dermatologist and Founder of Sobel Skin, recommends the Olay® Regenerist® Intensive Repair Treatment ($19) for sensitive skin types. “The retinyl propionate found in this product is a more tolerable form of vitamin A. It also has niacinamide and dimethicone, which [may] decrease the risk of [redness and dryness],” he explains.  Additionally, it contains vitamin B3 to help retain skin’s moisture content.

For best results, Dr. Sobel recommends applying the treatment daily to cleansed skin, with a focus on areas particularly prone to aging (such as the area around the eyes and on the forehead). “Follow with your usual facial moisturizer,” he adds.

La Roche-Posay® Redermic RTM Anti-Aging Retinol Serum

La Roche-Posay Pure Retinol Face Serum with Vitamin B3. Anti Aging Face Serum for Lines, Wrinkles & Premature Sun Damage to Resurface & Hydrate. Suitable for Sensitive Skin, 1.0 Fl. Oz
  • La Roche-Posay's Retinol B3 Pure Retinol Serum, a face serum for women and men, acts as a sun spot remover for face and wrinkle remover for face, leaving skin smoother, hydrated, and renewed.
  • This anti aging face serum, enriched with retinol for men and women, effectively reduces lines, wrinkles, and premature sun damage, making it a great choice for men & women stocking stuffers.

The La Roche-Posay® Redermic RTM Anti-Aging Retinol Serum ($57) offers major moisture with a lightweight gel formula, says Dr. Adarsh Vijay Mudgil, a celebrity dermatologist and Medical Director of Mudgil DermatologyTM. “It feels refreshing and elegant to the touch, and contains lipo hydroxy acid — a derivative of salicylic acid — to help exfoliate skin and increase cell turnover. It also won’t dry out your skin [as much as salicylic acid] with regular use,” he explains.

CeraVe® Skin Renewing Retinol Day Cream with SPF 30

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CeraVe Anti Aging Retinol Serum For Face, Encapsulated Retinol With Hyaluronic Acid, Niacinamide & Ceramides, Smooths Wrinkles & Fine Lines, Gentle Skin Brightening Serum, Fragrance Free, 1 Oz
  • [ RETINOL FOR FACE ] This anti aging serum leverages encapsulated retinol with MVE Technology to ensure efficient delivery within for slow release over time, supporting your protective skin barrier long after you’ve finished applying
  • [ WRINKLE SERUM ] Face serum formulated with retinol to refine texture and diminish fine lines. Wrinkle remover for face contains hyaluronic acid locking in moisture for lasting hydration & niacinamide to help calm and soothe the skin

The CeraVe® Skin Renewing Retinol Day Cream with SPF 30 ($15) is another good option for sensitive and/or dry skin types. Not only is the formula fragrance-free and hypoallergenic, but it also contains barrier-supporting ceramides to strengthen and repair fragile skin, notes Dr. Shari Marchbein, FAAD, a board-certified dermatologist and Assistant Professor of Dermatology at the NYU School of MedicineTM. Additionally, the product itself is non-irritating.

“[It’s] an encapsulated retinol for a slow release,” Marchbein says. She also notes that it contains SPF for protection against UVA/UVB rays. Apply the formula liberally 15 minutes before sun exposure and reapply at least every two hours. (Note: retinol can make skin more sensitive to sun, so it’s absolutely crucial to use SPF when you’re using the ingredient.)

Product prices may vary from the time this article was written.

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